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In rodents, physical exercise leads toaugmentation of long-term potentiation, hippocampalcell proliferation, increased dendritic arborization, andgreater density of dendritic spines for both aged animalsand animals exposed to stressful environments and inter-ventions (Archer, 2011). It results from a reprogramming of epithelial stemcells thatbegin to differentiate into new cell lineage.
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If no other anaestheticor opioid is given, the patient becomes respon-sive in 1 hr or so due to redistribution of thedrug (distribution t? of diazepam is 15 min),but amnesia persists for 2–3 hr and sedation for6 hr or more.
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While initial exposure to atumor-promoting agent produces a transient increase in cellgrowth, only the initiated cells within the tissue sustain thisincrease in cell proliferation and/or DNA synthesis withcontinual treatment to the agent. Abrupt onset of severe odynophagia, GERDsymptoms, and fever are common. This publication is not intended for use in clinical practice or the delivery of medical care.
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